Optimization studies (work package 2)

Purpose: To generate new knowledge to inform rational and individualized use of antibiotics.

Work package 2 includes optimization studies (both preclinical and clinical), which aim to bring forth new evidence about how antibiotics should be used and dosed optimally for individual patients, to achieve high therapeutic effecicacy and low risks of side effects/development of resistance. The selection of studies is based upon the national inventory of knowledge gaps (performed within WP1).

What we are working with right now:

• We've recently finished and published a studie that shows which precision is needed in dosing history when modelbased precision dosing is introduced (vancomycin and meropenem is included within this study). Read it.
• Performing a concentration study about betalactam antibiotics during treatment for endocarditis.The study is ongoing in Uppsala, Gothenburg and Lund.
• A clinical study with focus on prelonged infusion of meropenem and piperacillin to intensivecare patients.
• Different in-vitro studies (i.e. laboratorybased studies) where the possibility to enhance the effect of antibiotica through different combinations and doses is studied.

Work package leader: